Drug Interactions Analysis and Management

Hansten, P. D., & Horn, J. R. (2003). Drug Interactions Analysis and Management. Wolters Kluwer.

Type

Book

Intellectual base

Review or monograph

Year

2003

Link

https://archive.org/details/druginteractions0000hans

Cited from

engineering_design, pharmacology_toxicology

Cited by

2 citations across 2 artifacts.

Each citation links to the sentence it supports in the citing article.

Primes

• Compatibility
  • The danger is that users may assume compatibility is binary (yes or no) and fail to test edge cases.

    This sourceCanonical clinical reference on drug–drug interactions: ranks each interaction by its potential to alter patient outcomes and documents how drugs that are pairwise compatible with most agents can still cause fatal interactions with a few — the partial-compatibility hazard.

• Potentiation
  • Tolerance (mirror phenomenon): Tolerance is the opposite response direction under repeated exposure—decreased rather than increased responsiveness, a contrast Hansten and Horn (2003) carefully maintain throughout their drug-interaction analysis framework.

    This sourceCanonical clinical reference on drug–drug interactions: develops the ORCA classification ranking interactions from "avoid combination" to "no interaction expected," and documents how drugs that are pairwise compatible with most agents can still cause fatal interactions with a few—the partial-compatibility hazard.

Verification

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