Critical Period Plasticity in Local Cortical Circuits.¶
Hensch, T. K. (2005). Critical Period Plasticity in Local Cortical Circuits. Nature Reviews Neuroscience, 6(11), 877-888.
Cited by¶
3 citations across 3 artifacts.
Each citation links to the sentence it supports in the citing article.
Primes¶
- Critical Period
- The closing mechanism is concrete and identified: the maturation of inhibitory (parvalbumin) interneuron circuits and the consolidation of the extracellular matrix into perineuronal nets that physically restrain further rewiring.
This sourceIdentifies the maturation of parvalbumin inhibitory interneuron circuits and proteolytic consolidation of the extracellular matrix (perineuronal nets) as the mechanism that opens and closes the cortical critical period.
Supported in partVerified against the publisher's abstract
Hensch's abstract identifies the parvalbumin basket cell as the critical-period trigger and reports that perineuronal nets enwrap it, with enzymatic removal reactivating adult plasticity; it does not present both as the closing mechanism.
“with age they are preferentially enwrapped by perineuronal nets, the removal of which in adulthood (by chondroitinases) reactivates plasticity”
- The closing mechanism is concrete and identified: the maturation of inhibitory (parvalbumin) interneuron circuits and the consolidation of the extracellular matrix into perineuronal nets that physically restrain further rewiring.
- Readiness Window
- In developmental biology and neuroscience, critical periods govern visual-cortex plasticity, language acquisition, imprinting in precocial birds, and behavioural socialisation, each a bounded interval during which experience shapes structure and outside which the same experience produces no change.
This sourceReviews critical-period opening and closure, the maturation of inhibitory circuitry and perineuronal nets that close the window, and molecular reopening.
Supported in partVerified against the publisher's abstract
Hensch's abstract supports critical periods in visual-cortex ocular-dominance plasticity but says nothing about language acquisition, avian imprinting, or behavioural socialisation.
“Critical periods of brain development have been identified across sensory systems, but are best characterized in the visual cortex where the inputs from the two eyes first converge and compete for space, both functionally and structurally.”
- In developmental biology and neuroscience, critical periods govern visual-cortex plasticity, language acquisition, imprinting in precocial birds, and behavioural socialisation, each a bounded interval during which experience shapes structure and outside which the same experience produces no change.
Domain-specific¶
- Neuroplasticity
- The capacity for modification is not uniform: developmental critical periods — windows of elevated plastic sensitivity sculpted by the maturation of parvalbumin-expressing inhibitory interneurons and the closure of perineuronal nets — set the temporal envelope in which experience durably shapes circuitry, as in Hubel and Wiesel's ocular-dominance columns
This sourceReview reporting that experience shapes cortical circuits during early-postnatal critical periods, that in primary visual cortex the development is triggered by maturation of local inhibitory connections and their late-developing interneuron subset, and that consolidation of competing sensory inputs follows proteolytic reorganisation of the extracellular matrix within the window. Review of critical-period plasticity in local cortical circuits, tracing the window's triggering to maturation of local inhibitory connections and its consolidation to proteolytic reorganisation of the extracellular matrix.
Supported in partVerified against a saved copy of the source
“Neuronal circuits in the brain are shaped by experience during 'critical periods' in early postnatal life.”
- The capacity for modification is not uniform: developmental critical periods — windows of elevated plastic sensitivity sculpted by the maturation of parvalbumin-expressing inhibitory interneurons and the closure of perineuronal nets — set the temporal envelope in which experience durably shapes circuitry, as in Hubel and Wiesel's ocular-dominance columns
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