A modification of receptor theory

STEPHENSON, R. P. (1956). A modification of receptor theory. British Journal of Pharmacology and Chemotherapy, 11(4), 379-393.

Type

Journal article

Intellectual base

Primary research

Year

1956

DOI

10.1111/j.1476-5381.1956.tb00006.x

Link

https://doi.org/10.1111/j.1476-5381.1956.tb00006.x

Cited from

pharmacology_toxicology

Cited by

2 citations across 2 artifacts.

Each citation links to the sentence it supports in the citing article.

Primes

• Dose-Response Relationship
  • Dose-response is clarifying because it enforces explicit specification of the input and output metrics and their functional relationship—rescuing qualitative claims ("more exposure is worse") into quantitative, estimable, predictively-useful curves, in the spirit of Stephenson's (1956) modification of receptor theory, which separated affinity (binding to receptor) from efficacy (capacity to elicit response) and so disambiguated the parameters latent in any sigmoidal curve.

    This sourceDistinguishes affinity (binding) from efficacy (capacity to elicit response); supports D47-026 (dose-response curves encode two physically distinct parameters — potency vs maximal effect — refining Clark's occupancy-only theory).

• Receptor Saturation
  • As Stephenson (1956) first formalized in his modification of receptor theory,

    This sourceDistinguishes affinity (binding) from efficacy (capacity to elicit response) in receptor pharmacology; clarifies that dose-response curves encode two physically distinct parameters (potency vs maximal effect), refining Clark's earlier occupancy-only theory.

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