Altering the Genome by Homologous Recombination.¶
Capecchi, M. R. (1989). Altering the Genome by Homologous Recombination. Science, 1288-1292.
Cited by¶
1 citation across 1 artifact.
Each citation links to the sentence it supports in the citing article.
Primes¶
- Minimal Pairs
- Modern ablation is industrial-scale minimal-pair experimentation. Lesion and knockout studies. Compare an organism with area or gene X intact to one with X disabled; attribute behavioral change to X.
This sourceFoundational gene-targeting / knockout methodology — disabling a single gene to attribute a phenotype to it (the genetic minimal pair); work recognized by the 2007 Nobel Prize.
- Modern ablation is industrial-scale minimal-pair experimentation. Lesion and knockout studies. Compare an organism with area or gene X intact to one with X disabled; attribute behavioral change to X.
Verification¶
This reference passed the adversarial substantiation pipeline: it was checked to exist and to support the claim it is attached to. See how references were verified.
Registry ID ref:a40b93afed2f · see in the full table