Altering the Genome by Homologous Recombination.¶
Capecchi, M. R. (1989). Altering the Genome by Homologous Recombination. Science, 1288-1292.
Cited by¶
1 citation across 1 artifact.
Each citation links to the sentence it supports in the citing article.
Primes¶
- Minimal Pairs
- Modern ablation is industrial-scale minimal-pair experimentation. Lesion and knockout studies. Compare an organism with area or gene X intact to one with X disabled; attribute behavioral change to X.
This sourceFoundational gene-targeting / knockout methodology — disabling a single gene to attribute a phenotype to it (the genetic minimal pair); work recognized by the 2007 Nobel Prize.
Supported in partVerified against the publisher's abstract
The abstract states gene targeting puts a cloned-gene modification into a living cell's genome - the knockout half of the claim - but is silent on lesion studies and on behavioural attribution.
“Homologous recombination between DNA sequences residing in the chromosome and newly introduced, cloned DNA sequences (gene targeting) allows the transfer of any modification of the cloned gene into the genome of a living cell.”
- Modern ablation is industrial-scale minimal-pair experimentation. Lesion and knockout studies. Compare an organism with area or gene X intact to one with X disabled; attribute behavioral change to X.
Verification¶
Does it exist? Confirmed. This work's DOI resolves to a registered record, which fixes its identity. That is all it fixes.
Does it back the claim? Read against the text for 1 of 1 citation: 1 supported in part. Each verdict is shown under its citation below, with what in the work backs the sentence.
Support is checked per citation rather than per work — the same source can be cited soundly in one article and wrongly in another. Per-citation recording began recently, so a citation with no recorded check is a gap in the record rather than evidence it went unchecked.
See how references were verified.
Registry ID ref:a40b93afed2f · see in the full table