Hypoxia — a key regulatory factor in tumour growth¶
Harris. (2002). Hypoxia — a key regulatory factor in tumour growth. Nature Reviews Cancer.
Cited by¶
1 citation across 1 artifact.
Each citation links to the sentence it supports in the citing article.
Domain-specific¶
- Hypoxia
- Exercise and altitude physiology — acclimatisation through erythropoiesis, 2,3-BPG shifts, and ventilatory adaptation, with the HIF pathway underwriting both natural altitude tolerance and EPO doping. Tumour biology — chronic hypoxia in solid-tumour cores selecting HIF-active aggressive phenotypes and conferring radiotherapy resistance.
This sourceA review reporting that hypoxia induces a transcription programme promoting an aggressive tumour phenotype and that tumour hypoxia is associated with resistance to radiation therapy.
Supported in partVerified against the work's full text
“Hypoxia is a reduction in the normal level of tissue oxygen tension, and occurs during acute and chronic vascular disease, pulmonary disease and cancer. It induces a transcription programme that promotes an aggressive tumour phenotype.”
- Exercise and altitude physiology — acclimatisation through erythropoiesis, 2,3-BPG shifts, and ventilatory adaptation, with the HIF pathway underwriting both natural altitude tolerance and EPO doping. Tumour biology — chronic hypoxia in solid-tumour cores selecting HIF-active aggressive phenotypes and conferring radiotherapy resistance.
Verification¶
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Registry ID ref:a8d89959dd29 · see in the full table