The Blood-Brain Barrier

Pardridge, W. M. (2005). The Blood-Brain Barrier: Bottleneck in Brain Drug Development. NeuroRx, 2(1), 3-14.

Type

Journal article

Intellectual base

Primary research

Year

2005

DOI

10.1602/neurorx.2.1.3

Link

https://doi.org/10.1602/neurorx.2.1.3

Cited from

systems_cybernetics

Cited by

1 citation across 1 artifact.

Each citation links to the sentence it supports in the citing article.

Primes

• Permeability
  • The channel-and-transporter logic that explains ion selectivity explains blood-brain-barrier permeability, the design constraint for CNS pharmaceuticals.

    This sourceEstablishes blood-brain-barrier permeability (excluding ~100% of large-molecule and >98% of small-molecule drugs) via channels and transporters as the design constraint for CNS pharmaceuticals.

Verification

This reference passed the adversarial substantiation pipeline: it was checked to exist and to support the claim it is attached to. See how references were verified.

Registry ID ref:aa0c7e97abfa · see in the full table