A Mechanistic, Model-Based Approach to Safety Assessment in Clinical Development

Lippert, J., Brosch, M., von Kampen, O., Meyer, M., Siegmund, H. ‐., Schafmayer, C., Becker, T., et al. (2012). A Mechanistic, Model-Based Approach to Safety Assessment in Clinical Development. CPT: Pharmacometrics & Systems Pharmacology.

Type

Journal article

Intellectual base

Primary research

Year

2012

DOI

10.1038/psp.2012.14

Link

https://doi.org/10.1038/psp.2012.14

Cited by

1 citation across 1 artifact.

Domain-specific

• Adverse Event Prediction
  • Lippert and colleagues demonstrated a workflow integrating physiology, pharmacology, preclinical data, clinical information, genotype, and exposure to predict statin-associated myopathy rates under drug, dose, and patient extrapolation.

Verification

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Registry ID ref:aed8274e154a · see in the full table