Balanced Inhibition Underlies Tuning and Sharpens Spike Timing in Auditory Cortex¶
Wehr, M., & Zador, A. M. (2003). Balanced Inhibition Underlies Tuning and Sharpens Spike Timing in Auditory Cortex. Nature, 426, 442-446.
Cited by¶
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Primes¶
- Excitation-Inhibition Balance
- The concurrency commitment is experimentally confirmed: recordings show that excitatory and inhibitory conductances onto a neuron rise and fall together, tracking the same upstream stimulus rather than one switching off, so the pattern is constitutive, not corrective.
This sourceShows excitatory and inhibitory conductances co-vary with the same stimulus (concurrent, not corrective) and that inhibition arriving milliseconds after excitation sharpens temporal precision.
Supported in partVerified against the publisher's abstract
Abstract gives E/I receptive fields that nearly coincide and inhibition as strong as excitation — concurrent tuning — but describes a 1–4 ms excitatory-then-inhibitory sequence, not simultaneous rise and fall.
“The excitatory and inhibitory receptive fields cover almost exactly the same areas, in contrast to the predictions of classical lateral inhibition models. Thus, although inhibition is typically as strong as excitation, it is not necessary to establish tuning, even in the receptive field surround. However, inhibition and excitation occurred in a precise and stereotyped temporal sequence: an initial barrage of …”
- The concurrency commitment is experimentally confirmed: recordings show that excitatory and inhibitory conductances onto a neuron rise and fall together, tracking the same upstream stimulus rather than one switching off, so the pattern is constitutive, not corrective.
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