Plotkin's Vaccines¶
Plotkin, S. A., Orenstein, W. A., Offit, P. A., & Edwards, K. M. (2018). Plotkin's Vaccines. Elsevier.
Cited by¶
4 citations across 4 artifacts.
Each citation links to the sentence it supports in the citing article.
Primes¶
- Inoculation Theory
- Immunology. Literal vaccination: killed, attenuated, or subunit antigen triggers an adaptive response without full disease, and memory cells respond rapidly to real infection — the biological referent.
This sourceStandard reference on vaccine immunology: attenuated/killed/subunit antigens, immune memory, dosing, and adverse-event risk.
- Immunology. Literal vaccination: killed, attenuated, or subunit antigen triggers an adaptive response without full disease, and memory cells respond rapidly to real infection — the biological referent.
- Loading Dose
- And in vaccination strategy, front-loaded priming doses raise antibody titer quickly, followed by boosters that maintain.
This sourcePriming-dose-then-booster schedules that raise antibody titer quickly and then maintain it.
- And in vaccination strategy, front-loaded priming doses raise antibody titer quickly, followed by boosters that maintain.
- Mobilization
- The conversion-gap invariant is decisive: an organism's defense depends not on the raw size of its lymphocyte reservoir but on the conversion rate — how fast and completely the right clones expand and coordinate — which is why vaccination works by pre-expanding the reservoir and lowering the trigger threshold, raising conversion rather than total capacity.
This sourceVaccination works by pre-expanding the antigen-specific lymphocyte reservoir and lowering the activation threshold, raising conversion rate rather than total capacity.
- The conversion-gap invariant is decisive: an organism's defense depends not on the raw size of its lymphocyte reservoir but on the conversion rate — how fast and completely the right clones expand and coordinate — which is why vaccination works by pre-expanding the reservoir and lowering the trigger threshold, raising conversion rather than total capacity.
- Preparation
- Preparation licenses several structural moves. The standing-cost calculation: for any substrate, weigh the gain per triggering event times the trigger frequency against the standing cost of maintained preparation — below unity the system is over-prepared, far above it under-prepared. Perishability analysis: every primed state has a half-life — athletic warm-up dissipates in minutes, pre-cooked food in hours, vaccinated immunity in years
This sourceDocuments the waning of vaccine-induced immunity over years, motivating booster doses on the decay timescale.
- Preparation licenses several structural moves. The standing-cost calculation: for any substrate, weigh the gain per triggering event times the trigger frequency against the standing cost of maintained preparation — below unity the system is over-prepared, far above it under-prepared. Perishability analysis: every primed state has a half-life — athletic warm-up dissipates in minutes, pre-cooked food in hours, vaccinated immunity in years
Verification¶
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Links previously used in the corpus¶
Before the registry existed this work was also linked 2 other ways.
- https://shop.elsevier.com/books/plotkins-vaccines/orenstein/978-0-323-35761-6 ×1
- https://www.elsevier.com/books/plotkins-vaccines/plotkin/978-0-323-35761-6 ×1
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