Plotkin's Vaccines¶
Plotkin, S. A., Orenstein, W. A., Offit, P. A., & Edwards, K. M. (2018). Plotkin's Vaccines. Elsevier.
Cited by¶
4 citations across 4 artifacts.
Each citation links to the sentence it supports in the citing article.
Primes¶
- Inoculation Theory
- Immunology. Literal vaccination: killed, attenuated, or subunit antigen triggers an adaptive response without full disease, and memory cells respond rapidly to real infection — the biological referent.
This sourceStandard reference on vaccine immunology: attenuated/killed/subunit antigens, immune memory, dosing, and adverse-event risk.
- Immunology. Literal vaccination: killed, attenuated, or subunit antigen triggers an adaptive response without full disease, and memory cells respond rapidly to real infection — the biological referent.
- Loading Dose
- And in vaccination strategy, front-loaded priming doses raise antibody titer quickly, followed by boosters that maintain.
This sourcePriming-dose-then-booster schedules that raise antibody titer quickly and then maintain it.
- And in vaccination strategy, front-loaded priming doses raise antibody titer quickly, followed by boosters that maintain.
- Mobilization
- The conversion-gap invariant is decisive: an organism's defense depends not on the raw size of its lymphocyte reservoir but on the conversion rate — how fast and completely the right clones expand and coordinate — which is why vaccination works by pre-expanding the reservoir and lowering the trigger threshold, raising conversion rather than total capacity.
This sourceVaccination works by pre-expanding the antigen-specific lymphocyte reservoir and lowering the activation threshold, raising conversion rate rather than total capacity.
- The conversion-gap invariant is decisive: an organism's defense depends not on the raw size of its lymphocyte reservoir but on the conversion rate — how fast and completely the right clones expand and coordinate — which is why vaccination works by pre-expanding the reservoir and lowering the trigger threshold, raising conversion rather than total capacity.
- Preparation
- Preparation licenses several structural moves. The standing-cost calculation: for any substrate, weigh the gain per triggering event times the trigger frequency against the standing cost of maintained preparation — below unity the system is over-prepared, far above it under-prepared. Perishability analysis: every primed state has a half-life — athletic warm-up dissipates in minutes, pre-cooked food in hours, vaccinated immunity in years
This sourceDocuments the waning of vaccine-induced immunity over years, motivating booster doses on the decay timescale.
Supported in partVerified against the publisher's abstract
A vaccines reference whose stated coverage includes 'duration of immunity'; it can carry only the claim's vaccine half-life instance, not the standing-cost rule.
“its stability, immunogenicity, efficacy, duration of immunity, adverse events, indications, contraindications, precautions, administration with other vaccines, and disease-control strategies”
- Preparation licenses several structural moves. The standing-cost calculation: for any substrate, weigh the gain per triggering event times the trigger frequency against the standing cost of maintained preparation — below unity the system is over-prepared, far above it under-prepared. Perishability analysis: every primed state has a half-life — athletic warm-up dissipates in minutes, pre-cooked food in hours, vaccinated immunity in years
Verification¶
Does it exist? Not checked yet. This entry carries no identifier to resolve. It was extracted from the citation as written in the article, normalized, and deduplicated against the rest of the registry.
Does it back the claim? Read against the text for 1 of 4 citations: 1 supported in part. Each verdict is shown under its citation below, with what in the work backs the sentence.
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Links previously used in the corpus¶
Before the registry existed this work was also linked 2 other ways.
- https://shop.elsevier.com/books/plotkins-vaccines/orenstein/978-0-323-35761-6 ×1
- https://www.elsevier.com/books/plotkins-vaccines/plotkin/978-0-323-35761-6 ×1
Registry ID ref:af85907e31af · see in the full table