Pharmacokinetic/pharmacodynamic parameters¶
Craig, W. A. (1998). Pharmacokinetic/pharmacodynamic parameters: Rationale for antibacterial dosing of mice and men. Clinical Infectious Diseases, 26(1), 1-10.
Cited by¶
1 citation across 1 artifact.
Each citation links to the sentence it supports in the citing article.
Primes¶
- Therapeutic Window
- Failure mode: a narrow-window intervention is dismissed or abandoned rather than managed with the appropriate operational infrastructure (monitoring, dose adjustment, patient education), resulting in loss of its benefit to the patient or system.
This sourceCanonical antibiotic PK/PD framework: identifies time-above-MIC, AUC/MIC, and peak/MIC as the correct efficacy targets for distinct antibiotic classes, showing that a narrow apparent therapeutic window often dissolves once the appropriate target is identified.
- Failure mode: a narrow-window intervention is dismissed or abandoned rather than managed with the appropriate operational infrastructure (monitoring, dose adjustment, patient education), resulting in loss of its benefit to the patient or system.
Verification¶
Does it exist? Not checked yet. This entry carries no identifier to resolve. It was extracted from the citation as written in the article, normalized, and deduplicated against the rest of the registry.
Does it back the claim? Not recorded. The single citation of this work carries no recorded support check.
Support is checked per citation rather than per work — the same source can be cited soundly in one article and wrongly in another. Per-citation recording began recently, so a citation with no recorded check is a gap in the record rather than evidence it went unchecked.
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Registry ID ref:b13286c73a1d · see in the full table