Immunobiology

Janeway, C. A., Travers, P., Walport, M., & Shlomchik, M. (2001). Immunobiology: The Immune System in Health and Disease.

Type

Book

Intellectual base

Review or monograph

Year

2001

Link

https://www.ncbi.nlm.nih.gov/books/NBK10757/

Cited from

computer_science, neuroscience, philosophy, sociology_anthropology, systems_cybernetics

Cited by

7 citations across 7 artifacts.

Each citation links to the sentence it supports in the citing article.

Primes

• Authentication
  • Medicine — patient identification before procedures, sample chain-of-custody, and accreditation of providers. Scholarship and journalism — source authentication, document and image verification, and the vouching of anonymous sources. Biology and social systems — molecular self/non-self discrimination as a literal authentication mechanism, and vouching, credentialing, and reputation tokens as their social counterparts.

    This sourceDescribes molecular self/non-self discrimination — the immune system as a literal claim-evidence-verdict authentication mechanism.

• Capability Separation
  • Strikingly, it appears in biology: an organism's genome is uniquely empowered to issue legitimate self-marker complexes, while immune cells educated to distinguish self from non-self verify, with molecular-shape matching as the forgery-prevention mechanism — a non-human instance that confirms the pattern is genuinely structural rather than merely institutional.

    This sourceStandard immunology text on MHC self-marker presentation and immune self/non-self recognition by molecular-shape specificity.

• Mobilization
  • In immunology, a vast reservoir of naive lymphocytes is triggered by antigen recognition into clonal expansion (activation), cytokine signaling (coordination), and effector function (channeled action), with contraction returning most cells to latency and leaving memory cells.
• Out Of Distribution Detection
  • Immunology: self/non-self discrimination is structurally an in/out-of-distribution check before mounting a response.

    This sourceStandard immunology text; its account of self/non-self discrimination is the biological analogue of an in-/out-of-distribution check that gates the immune response.

• Sparse Coding
  • The pool is the naive lymphocyte repertoire — on the order of \(10^7\)–\(10^8\) distinct B- and T-cell clones, each bearing a different antigen receptor, vastly more than are needed for any single infection.

    This sourceStandard immunology text documenting the scale of the naive lymphocyte repertoire and antigen-driven clonal expansion of the matching subset.

• Tempo Mismatch
  • From immunology, the innate-versus-adaptive timescale distinction names the binding constraint on outbreak resolution in a form that transfers to any defense whose response lags its threat.
• Tolerance Paradox
  • In immunology, the adaptive immune system must tolerate self-tissue, yet the machinery of tolerance must itself exclude cells that would attack that machinery — and the pathologies of tolerance, autoimmunity and over-tolerance, occupy both sides of the same bind.

    This sourceStandard reference on immunological self-tolerance, regulatory mechanisms, and autoimmunity as failures of tolerance.

Verification

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