Rang and Dale's Pharmacology¶
Ritter, J. M., Flower, R. J., Henderson, G., & Rang, H. P. (2016). Rang and Dale's Pharmacology. Elsevier.
Cited by¶
1 citation across 1 artifact.
Each citation links to the sentence it supports in the citing article.
Primes¶
- Intervention-Coupled Harm
- In pharmacology and medicine, adverse drug events from on-target effects are the canonical case: a tumour-killing drug also kills bone-marrow stem cells because both divide rapidly, and radiation therapy is carcinogenic because the DNA damage that destroys cancer cells is also the carcinogenic mechanism — the therapeutic window is the operational consequence.
This sourceEstablishes on-target adverse drug effects and the therapeutic window/index as the operational consequence of benefit and harm sharing one mechanism.
- In pharmacology and medicine, adverse drug events from on-target effects are the canonical case: a tumour-killing drug also kills bone-marrow stem cells because both divide rapidly, and radiation therapy is carcinogenic because the DNA damage that destroys cancer cells is also the carcinogenic mechanism — the therapeutic window is the operational consequence.
Verification¶
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