Homeostasis, inflammation, and disease susceptibility

Kotas, M. E., & Medzhitov, R. (2015). Homeostasis, inflammation, and disease susceptibility. Cell, 160(5), 816-827.

Type

Journal article

Intellectual base

Primary research

Year

2015

Volume

160

Issue

5

Pages

816-827

DOI registrant

Elsevier

Link

https://doi.org/10.1016/j.cell.2015.02.010matched

Cited from

biology_ecology

Cited by

1 citation across 1 artifact.

Primes

• Homeostasis
  • The Gaia hypothesis (Lovelock, Margulis) extends homeostasis to planetary scale as a speculative-but-testable framework. Economics and organizations: Central-bank inflation targeting (interest-rate adjustment as the actuator, inflation as the regulated variable, 2% as a common setpoint); automatic stabilizers in fiscal policy (unemployment insurance, progressive taxation); corporate budget-variance-and-correction cycles; supply-chain inventory regulation with reorder points and safety stocks. Software and infrastructure: Autoscaling (cloud services adjusting instance count to maintain latency or utilization targets — a direct engineering homeostasis); rate-limiting (protecting services from overload); load balancing; self-healing clusters (restarting failed nodes); circuit breakers (see overloaded term #336/#42) — many resilience patterns are homeostatic. Psychology and affect regulation: Allostatic stress response (HPA axis regulation of cortisol and catecholamines); emotion regulation (cognitive reappraisal as homeostatic adjustment toward acceptable affect range); circadian regulation of sleep/wake and hormone cycles. Social systems: Norm-enforcement mechanisms (social sanctions as corrective actions when behavior deviates from norms); institutional self-correction; metaphorical extension of homeostasis to organizational culture (used cautiously — social systems often lack the sharp sensor-actuator structure of physiological ones).

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