Extracellular Matrix Molecular Remodeling in Human Liver Fibrosis Evolution.

Baiocchini, A., Montaldo, C., Conigliaro, A., Grimaldi, A., Correani, V., Mura, F., Ciccosanti, F., et al. (2016). Extracellular Matrix Molecular Remodeling in Human Liver Fibrosis Evolution. PLOS ONE, 11(3).

Type

Journal article

Intellectual base

Primary research

Year

2016

Volume

11

Issue

3

DOI

10.1371/journal.pone.0151736

DOI registrant

Public Library of Science

Link

https://doi.org/10.1371/journal.pone.0151736

Cited from

chemistry_materials

Cited by

1 citation across 1 artifact.

Each citation links to the sentence it supports in the citing article.

Primes

• Microstructure
  • Tissue biology — function is mediated by cellular microstructure (cell-type ratios, extracellular-matrix architecture, vascularization), not cell-type composition alone; healthy and fibrotic livers can share cell populations yet differ sharply in microstructure and function.

    This sourceDocuments how liver function is mediated by tissue microstructure — extracellular-matrix architecture and its remodeling — so fibrotic and healthy livers differ sharply in matrix architecture and function rather than in cell-type composition alone.

    Supported in partVerified against the work's full text

    The paper shows fibrotic ECM remodeling changes matrix stiffness, density and composition and links ECM to liver-specific function; it does not compare cell populations or measure function in healthy versus fibrotic livers.

    “several ECM components, such as collagen, fibronectin and laminin, are responsible also for promoting the expression of liver-specific functions and cell differentiation”

    Read by an automated reader; not a human review. How support was checked

Verification

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