Statistics in Medicine — Reporting of Subgroup Analyses in Clinical Trials.

Wang, R., Lagakos, S. W., Ware, J. H., Hunter, D. J., & Drazen, J. M. (2007). Statistics in Medicine — Reporting of Subgroup Analyses in Clinical Trials. New England Journal of Medicine, 357(21), 2189-2194.

Type

Journal article

Intellectual base

Primary research

Year

2007

DOI

10.1056/nejmsr077003

Link

https://doi.org/10.1056/NEJMsr077003

Cited from

organizational_management

Cited by

2 citations across 2 artifacts.

Each citation links to the sentence it supports in the citing article.

Primes

• Objective Creep
  • In research, a study designed for one hypothesis adds secondary aims and sub-group analyses until the primary aim is under-powered.

    This sourceShows that accumulating secondary and subgroup analyses inflates error and that such analyses are typically under-powered relative to the primary aim.

Mechanisms

• Subgroup Disaggregation Audit
  • This is the multiple-comparisons trap

    This sourceWarns that post hoc subgroup analyses are vulnerable to multiplicity and inflated false-positive findings.

Verification

This reference passed the adversarial substantiation pipeline: it was checked to exist and to support the claim it is attached to. See how references were verified.

Registry ID ref:b476d67917dd · see in the full table