Preservation of Duplicate Genes by Complementary, Degenerative Mutations.¶
Force, A., Lynch, M., Pickett, F. B., Amores, A., Yan, Y., & Postlethwait, J. (1999). Preservation of Duplicate Genes by Complementary, Degenerative Mutations. Genetics, 151(4), 1531-1545.
Cited by¶
2 citations across 2 artifacts.
Each citation links to the sentence it supports in the citing article.
Primes¶
- Functional Redundancy (Degeneracy)
- Force, Lynch, Pickett, Amores, Yan, and Postlethwait (1999) provide a striking example of this clarifying move in evolutionary genetics: their duplication-degeneration-complementation (DDC) model shows that gene duplicates are preserved when they sub-functionalize, each losing some original capability while the pair retains the full function — a pattern indistinguishable from generic "robustness" until the redundancy frame names it precisely.
This sourceIntroduces the duplication-degeneration-complementation (DDC) model: duplicates are preserved when each sub-functionalizes while jointly retaining the original function; directly supports the clarity-section DDC example.
Supported in partVerified against the publisher's abstract
The paper's own abstract states the DDC model: duplicates persist by partitioning ancestral functions, each copy losing subfunctions while the pair keeps the original role.
“The duplication-degeneration-complementation (DDC) model predicts that (1) degenerative mutations in regulatory elements can increase rather than reduce the probability of duplicate gene preservation and (2) the usual mechanism of duplicate gene preservation is the partitioning of ancestral functions rather than the evolution of new functions.”
- Force, Lynch, Pickett, Amores, Yan, and Postlethwait (1999) provide a striking example of this clarifying move in evolutionary genetics: their duplication-degeneration-complementation (DDC) model shows that gene duplicates are preserved when they sub-functionalize, each losing some original capability while the pair retains the full function — a pattern indistinguishable from generic "robustness" until the redundancy frame names it precisely.
- Substitutability
- Functional redundancy in genetic pathways, immune response, and metabolic networks, with Force, Lynch, Pickett, and Postlethwait (1999) showing how duplicated genes are preserved precisely because complementary degenerative mutations let each paralog substitute for the other in different regulatory contexts.
This sourceDevelops the duplication-degeneration-complementation (DDC) model of paralog retention: duplicated genes are preserved in the genome because complementary loss-of-function mutations partition ancestral functions, making each copy substitutable for the other only in restricted contexts.
Supported in partVerified against the publisher's abstract
The abstract states the DDC model - complementary degenerative mutations in different regulatory elements preserve both duplicate genes - backing the claim's attributed clause, but it never mentions immune response or metabolic networks.
“we show how complementary degenerative mutations in different regulatory elements of duplicated genes can facilitate the preservation of both duplicates, thereby increasing long-term opportunities for the evolution of new gene functions.”
- Functional redundancy in genetic pathways, immune response, and metabolic networks, with Force, Lynch, Pickett, and Postlethwait (1999) showing how duplicated genes are preserved precisely because complementary degenerative mutations let each paralog substitute for the other in different regulatory contexts.
Verification¶
Does it exist? Confirmed. This work's DOI resolves to a registered record, which fixes its identity. That is all it fixes.
Does it back the claim? Read against the text for 2 of 2 citations: 2 supported in part. Each verdict is shown under its citation below, with what in the work backs the sentence.
Support is checked per citation rather than per work — the same source can be cited soundly in one article and wrongly in another. Per-citation recording began recently, so a citation with no recorded check is a gap in the record rather than evidence it went unchecked.
See how references were verified.
Registry ID ref:b4fbaa6ed772 · see in the full table