Preservation of Duplicate Genes by Complementary, Degenerative Mutations.¶
Force, A., Lynch, M., Pickett, F. B., Amores, A., Yan, Y., & Postlethwait, J. (1999). Preservation of Duplicate Genes by Complementary, Degenerative Mutations. Genetics, 151(4), 1531-1545.
Cited by¶
2 citations across 2 artifacts.
Each citation links to the sentence it supports in the citing article.
Primes¶
- Functional Redundancy (Degeneracy)
- Force, Lynch, Pickett, Amores, Yan, and Postlethwait (1999) provide a striking example of this clarifying move in evolutionary genetics: their duplication-degeneration-complementation (DDC) model shows that gene duplicates are preserved when they sub-functionalize, each losing some original capability while the pair retains the full function — a pattern indistinguishable from generic "robustness" until the redundancy frame names it precisely.
This sourceIntroduces the duplication-degeneration-complementation (DDC) model: duplicates are preserved when each sub-functionalizes while jointly retaining the original function; directly supports the clarity-section DDC example.
- Force, Lynch, Pickett, Amores, Yan, and Postlethwait (1999) provide a striking example of this clarifying move in evolutionary genetics: their duplication-degeneration-complementation (DDC) model shows that gene duplicates are preserved when they sub-functionalize, each losing some original capability while the pair retains the full function — a pattern indistinguishable from generic "robustness" until the redundancy frame names it precisely.
- Substitutability
- Functional redundancy in genetic pathways, immune response, and metabolic networks, with Force, Lynch, Pickett, and Postlethwait (1999) showing how duplicated genes are preserved precisely because complementary degenerative mutations let each paralog substitute for the other in different regulatory contexts.
This sourceDevelops the duplication-degeneration-complementation (DDC) model of paralog retention: duplicated genes are preserved in the genome because complementary loss-of-function mutations partition ancestral functions, making each copy substitutable for the other only in restricted contexts.
- Functional redundancy in genetic pathways, immune response, and metabolic networks, with Force, Lynch, Pickett, and Postlethwait (1999) showing how duplicated genes are preserved precisely because complementary degenerative mutations let each paralog substitute for the other in different regulatory contexts.
Verification¶
This reference passed the adversarial substantiation pipeline: it was checked to exist and to support the claim it is attached to. See how references were verified.
Registry ID ref:b4fbaa6ed772 · see in the full table