The Mode of Action of Drugs on Cells¶
Clark, A. J. (1933). The Mode of Action of Drugs on Cells.
Cited by¶
1 citation across 1 artifact.
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Primes¶
- Dose-Response Relationship
- The construct is more specific, in the tradition Clark (1933) consolidated in The Mode of Action of Drugs on Cells: it presupposes a dose—a quantified exposure—and a response that is measured on a specific scale, and it characterizes the functional form rather than merely noting that more-input-means-more-output.
This sourceEdward Arnold & Co. Foundational quantitative pharmacology establishing receptor-occupancy theory and curve-fitting; supports D47-020 (dose-response is more than monotonic correlation — it requires an explicit functional form with estimated parameters).
- The construct is more specific, in the tradition Clark (1933) consolidated in The Mode of Action of Drugs on Cells: it presupposes a dose—a quantified exposure—and a response that is measured on a specific scale, and it characterizes the functional form rather than merely noting that more-input-means-more-output.
Verification¶
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