Single-Cell Responses in Striate Cortex of Kittens Deprived of Vision in One Eye.¶
Wiesel, T. N., & Hubel, D. H. (1963). Single-Cell Responses in Striate Cortex of Kittens Deprived of Vision in One Eye. Journal of Neurophysiology, 26(6), 1003-1017.
Cited by¶
3 citations across 3 artifacts.
Each citation links to the sentence it supports in the citing article.
Primes¶
- Pruning
- The essential grow-then-prune ordering is on display: one cannot prune a not-yet-grown cortex (there is no surplus to select from), and one cannot reach the mature specialized wiring by growing it directly, because the activity signal that identifies the right subset only exists once the surplus is in place and being driven by experience — the classic demonstration being monocular deprivation, where closing one eye biases the activity signal and the deprived eye's connections are pruned away.
This sourceThe monocular-deprivation experiments showing a biased activity signal prunes the deprived eye's connections.
Supported in partVerified against the work's full text
Wiesel and Hubel show monocular deprivation leaves cortical cells unresponsive to the deprived eye; they do not describe pruning, an initial surplus, or grow-then-prune ordering.
“We conclude that monocular deprivation in kittens can lead to un- responsiveness of cortical cells to stimulation of the deprived eye”
- The essential grow-then-prune ordering is on display: one cannot prune a not-yet-grown cortex (there is no surplus to select from), and one cannot reach the mature specialized wiring by growing it directly, because the activity signal that identifies the right subset only exists once the surplus is in place and being driven by experience — the classic demonstration being monocular deprivation, where closing one eye biases the activity signal and the deprived eye's connections are pruned away.
- Readiness Window
- The cortical critical period for monocular deprivation makes this concrete: suturing one eye closed during a developmentally bounded interval produces permanent loss of cortical responsiveness to that eye even after reversal, while the same procedure on an adult produces full recovery
This sourceDemonstrates that monocular deprivation during a critical period produces permanent loss of cortical responsiveness, absent in adults.
Supported in partVerified against the work's full text
Wiesel and Hubel show profound cortical unresponsiveness to the deprived eye in kittens and no effect in an adult cat, but do not test long-term irreversibility or an adult 'recovery'.
“The susceptibility of very young kittens to a few months of visual dep- rivation apparently does not extend to older animals, since there is a de- tectable lessening of effects when deprivation is begun at 2 months, and an absence of behavioral or physiological effects in adults.”
- The cortical critical period for monocular deprivation makes this concrete: suturing one eye closed during a developmentally bounded interval produces permanent loss of cortical responsiveness to that eye even after reversal, while the same procedure on an adult produces full recovery
Domain-specific¶
- Neuroplasticity
- David Hubel and Torsten Wiesel's monocular-deprivation experiments (work from the 1960s, Nobel Prize 1981) are the founding demonstration
Supported in partVerified against a saved copy of the source
“SINGLE-CELL RESPONSES IN STRIATE CORTEX OF KITTENS DEPRIVED OF VISION IN ONE EYE.”
- David Hubel and Torsten Wiesel's monocular-deprivation experiments (work from the 1960s, Nobel Prize 1981) are the founding demonstration
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