Principles of Population Genetics

Hartl, D. L., & Clark, A. G. (2007). Principles of Population Genetics. Sinauer Associates.

Type

Book

Intellectual base

Textbook

Year

2007

Link

https://global.oup.com/academic/product/principles-of-population-genetics-9780878933082

Cited from

biology_ecology, mathematics, philosophy

Cited by

4 citations across 4 artifacts.

Each citation links to the sentence it supports in the citing article.

Primes

• Eventual Realisation of Possibility
  • Evolution: any beneficial or harmful mutation within the mutation rate's reach will appear in some genome over evolutionary time.

    This sourceStandard population-genetics text treating mutation as a force whose rate, compounded over generations, makes the appearance of any reachable mutation effectively certain over evolutionary time.

• Founder Effect
  • The parent population carries a recessive allele at frequency \(p = 0.001\).

    This sourceStandard reference deriving binomial sampling of allele frequencies, sampling variance scaling with 1/(2N), and the genetics of founder events and bottlenecks.

• Zero-Force Null Baseline
  • A researcher finding that observed genotype frequencies at a locus depart from Hardy-Weinberg, with heterozygotes under-represented, treats the deficit not as model failure but as a named-attribution problem: it is consistent with assortative mating, population substructure (the Wahlund effect), selection against heterozygotes, or inbreeding, each a specific perturbing force investigable by a targeted experiment — spatial sampling for Wahlund, mate-choice observation for assortative mating, fitness assays for selection.

    This sourceStandard text: reads Hardy-Weinberg departures (heterozygote deficit) as attributable to inbreeding (F), the Wahlund effect, assortative mating, or selection, each testable by a targeted method.

Domain-specific

• General selection model
  • … frequencies, ploidy and mating assumptions, genotype fitnesses and timing, mean fitness, recurrence or delta equation, dominance, equilibria and excluded mutation migration and drift are explicit. to An applied instance preserves the invariant under changed notation, scale, dataset, jurisdiction, or implementation..

Verification

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Links previously used in the corpus

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• https://global.oup.com/ukhe/product/principles-of-population-genetics-9780197778739 ×1
• https://global.oup.com/ushe/product/principles-of-population-genetics-9780878933082 ×1

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