Long-Lasting Potentiation of Synaptic Transmission in the Dentate Area of the Anaesthetized Rabbit Following Stimulation of the Perforant Path.¶
Bliss, T. V. P., & Lømo, T. (1973). Long-Lasting Potentiation of Synaptic Transmission in the Dentate Area of the Anaesthetized Rabbit Following Stimulation of the Perforant Path. Journal of Physiology, 232(2), 331-356.
Cited by¶
3 citations across 3 artifacts.
Each citation links to the sentence it supports in the citing article.
Primes¶
- Hebbian Learning
- Neuroscience. The canonical source: long-term potentiation, spike-timing-dependent plasticity, cerebellar plasticity.
This sourceFirst demonstration of long-term potentiation, the synaptic substrate of Hebbian plasticity.
Supported in partVerified against the publisher's abstract
Abstract reports long-lasting potentiation in rabbit dentate gyrus, supporting only the LTP part, not STDP or cerebellar plasticity.
“In fifteen out of eighteen rabbits the population response recorded from granule cells in the dentate area to single perforant path volleys was potentiated for periods ranging from 30 min to 10 hr”
- Neuroscience. The canonical source: long-term potentiation, spike-timing-dependent plasticity, cerebellar plasticity.
- Potentiation
- Neuroscience and learning: Long-term potentiation (LTP), the paradigmatic cellular and synaptic model of learning and memory first reported by Bliss and Lømo (1973) in the dentate area of anaesthetized rabbit and elaborated mechanistically over subsequent decades, in which high-frequency presynaptic activity triggers NMDA-receptor calcium influx, downstream signaling cascades, and insertion of AMPA receptors, resulting in a lasting (hours to lifetime) increase in excitatory postsynaptic potential (EPSP) amplitude evoked by subsequent test stimuli; behavioral sensitization to repeated stimulant exposure (psychostimulants, glucocorticoids), where motor and reward responses increase with repeated dosing, opposite to tolerance; activity-dependent synaptic plasticity more broadly, which forms the mechanistic basis for memory encoding and consolidation.
Supported in partVerified against the publisher's abstract
Bliss & Lømo 1973 backs the original dentate-area LTP finding in anaesthetized rabbits and a lasting rise in the population EPSP, but nothing on NMDA/AMPA mechanisms or sensitization.
“In fifteen out of eighteen rabbits the population response recorded from granule cells in the dentate area to single perforant path volleys was potentiated for periods ranging from 30 min to 10 hr after one or more conditioning trains at 10–20/sec for 10–15 sec, or 100/sec for 3–4 sec.”
- Neuroscience and learning: Long-term potentiation (LTP), the paradigmatic cellular and synaptic model of learning and memory first reported by Bliss and Lømo (1973) in the dentate area of anaesthetized rabbit and elaborated mechanistically over subsequent decades, in which high-frequency presynaptic activity triggers NMDA-receptor calcium influx, downstream signaling cascades, and insertion of AMPA receptors, resulting in a lasting (hours to lifetime) increase in excitatory postsynaptic potential (EPSP) amplitude evoked by subsequent test stimuli; behavioral sensitization to repeated stimulant exposure (psychostimulants, glucocorticoids), where motor and reward responses increase with repeated dosing, opposite to tolerance; activity-dependent synaptic plasticity more broadly, which forms the mechanistic basis for memory encoding and consolidation.
Domain-specific¶
- Synaptic Plasticity
- The phenomenon encompasses a family of distinct mechanisms that differ in direction, timescale, and induction requirements: long-term potentiation (LTP) is a durable increase in synaptic strength, first characterised in hippocampal perforant-path synapses by Bliss and Lømo (1973)
Supported in partVerified against the publisher's abstract
“the population response recorded from granule cells in the dentate area to single perforant path volleys was potentiated for periods ranging from 30 min to 10 hr”
- The phenomenon encompasses a family of distinct mechanisms that differ in direction, timescale, and induction requirements: long-term potentiation (LTP) is a durable increase in synaptic strength, first characterised in hippocampal perforant-path synapses by Bliss and Lømo (1973)
Verification¶
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