Long-Lasting Potentiation of Synaptic Transmission in the Dentate Area of the Anaesthetized Rabbit Following Stimulation of the Perforant Path.

Bliss, T. V. P., & Lømo, T. (1973). Long-Lasting Potentiation of Synaptic Transmission in the Dentate Area of the Anaesthetized Rabbit Following Stimulation of the Perforant Path. Journal of Physiology, 232(2), 331-356.

Type

Journal article

Intellectual base

Primary research

Year

1973

DOI

10.1113/jphysiol.1973.sp010273

Link

https://doi.org/10.1113/jphysiol.1973.sp010273

Cited from

neuroscience, pharmacology_toxicology

Cited by

2 citations across 2 artifacts.

Each citation links to the sentence it supports in the citing article.

Primes

• Hebbian Learning
  • Neuroscience. The canonical source: long-term potentiation, spike-timing-dependent plasticity, cerebellar plasticity.

    This sourceFirst demonstration of long-term potentiation, the synaptic substrate of Hebbian plasticity.

• Potentiation
  • Neuroscience and learning: Long-term potentiation (LTP), the paradigmatic cellular and synaptic model of learning and memory first reported by Bliss and Lømo (1973) in the dentate area of anaesthetized rabbit and elaborated mechanistically over subsequent decades, in which high-frequency presynaptic activity triggers NMDA-receptor calcium influx, downstream signaling cascades, and insertion of AMPA receptors, resulting in a lasting (hours to lifetime) increase in excitatory postsynaptic potential (EPSP) amplitude evoked by subsequent test stimuli; behavioral sensitization to repeated stimulant exposure (psychostimulants, glucocorticoids), where motor and reward responses increase with repeated dosing, opposite to tolerance; activity-dependent synaptic plasticity more broadly, which forms the mechanistic basis for memory encoding and consolidation.

Verification

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