Evaluation of methods for estimating population pharmacokinetic parameters¶
Sheiner, L. B., & Beal, S. L. (1980). Evaluation of methods for estimating population pharmacokinetic parameters. Journal of Pharmacokinetics and Biopharmaceutics, 8(6), 553-571.
Cited by¶
1 citation across 1 artifact.
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Primes¶
- PK/PD Modeling (Pharmacokinetics / Pharmacodynamics)
- This hybridity is distinctive: PK/PD models are not purely data-driven (they assume structure) nor purely mechanistic (they fit parameters to data), but rather structure-informed calibration, where the structure comes from physiology and pharmacology, and the calibration comes from trial data.
This sourceIntroduces nonlinear mixed-effects modeling (NONMEM) for population PK parameter estimation from sparse routine clinical data; methodological backbone of population PK/PD analysis.
- This hybridity is distinctive: PK/PD models are not purely data-driven (they assume structure) nor purely mechanistic (they fit parameters to data), but rather structure-informed calibration, where the structure comes from physiology and pharmacology, and the calibration comes from trial data.
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