Comparison of Outcomes of Phase II Studies and Subsequent Randomized Control Studies Using Identical Chemotherapeutic Regimens¶
Zia. (2005). Comparison of Outcomes of Phase II Studies and Subsequent Randomized Control Studies Using Identical Chemotherapeutic Regimens. Journal of Clinical Oncology.
Cited by¶
1 citation across 1 artifact.
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Domain-specific¶
- Type M Error
- Underpowered psychology, economics, and biomedicine — the original critique target: surprising effects that shrink dramatically on higher-powered replication. Early-phase clinical trials — effects clearing p < 0.05 that Phase III systematically fails to recover (a known regularity in oncology and cardiovascular medicine)
This sourcePromising phase II chemotherapy results frequently not reproduced in phase III trials of identical regimens, 81% of which showed lower response rates.
Supported in partVerified against the source
- Underpowered psychology, economics, and biomedicine — the original critique target: surprising effects that shrink dramatically on higher-powered replication. Early-phase clinical trials — effects clearing p < 0.05 that Phase III systematically fails to recover (a known regularity in oncology and cardiovascular medicine)
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