The Structure of the Potassium Channel¶
Doyle, D. A., Cabral, J. M., Pfuetzner, R. A., Kuo, A., Gulbis, J. M., Cohen, S. L., Chait, B. T., et al. (1998). The Structure of the Potassium Channel: Molecular Basis of K+ Conduction and Selectivity. Science, 280(5360), 69-77.
Cited by¶
1 citation across 1 artifact.
Each citation links to the sentence it supports in the citing article.
Primes¶
- Permeability
- The selectivity profile is exquisite and type-selective: a potassium channel passes K\(^+\) a thousand-fold more readily than Na\(^+\), by matching pore geometry and charge to the target ion — selectivity by Kind (Type Theory), engineered into the pathway.
This sourceStructural basis of the potassium channel's selectivity filter, which coordinates K+ but excludes the smaller Na+ via pore geometry and carbonyl chemistry.
Supported in partVerified against the publisher's abstract
The abstract supports selectivity by pore chemistry: main-chain carbonyls coordinate K+ but not the smaller Na+; it does not state the thousand-fold K+/Na+ ratio.
“Main chain carbonyl oxygen atoms from the K + channel signature sequence line the selectivity filter, which is held open by structural constraints to coordinate K + ions but not smaller Na + ions.”
- The selectivity profile is exquisite and type-selective: a potassium channel passes K\(^+\) a thousand-fold more readily than Na\(^+\), by matching pore geometry and charge to the target ion — selectivity by Kind (Type Theory), engineered into the pathway.
Verification¶
Does it exist? Confirmed. This work's DOI resolves to a registered record, which fixes its identity. That is all it fixes.
Does it back the claim? Read against the text for 1 of 1 citation: 1 supported in part. Each verdict is shown under its citation below, with what in the work backs the sentence.
Support is checked per citation rather than per work — the same source can be cited soundly in one article and wrongly in another. Per-citation recording began recently, so a citation with no recorded check is a gap in the record rather than evidence it went unchecked.
See how references were verified.
Registry ID ref:bb381231d58a · see in the full table