Protein Purification¶
Scopes, R. K. (1994). Protein Purification: Principles and Practice. Springer.
Cited by¶
1 citation across 1 artifact.
Each citation links to the sentence it supports in the citing article.
Mechanisms¶
- pH or Ionic-Strength Shift
- Its failure mode is that charge effects are exquisitely sensitive and coupled: a pH meant to precipitate one protein may co-precipitate others, and a salt that helps at one concentration hurts at another, so selectivity is easily lost.
This sourceDistinguishes low-salt solubility from high-salt salting out and treats conventional precipitation as an empirical, limited-selectivity operation whose outcome changes with concentration and protein properties.
- Its failure mode is that charge effects are exquisitely sensitive and coupled: a pH meant to precipitate one protein may co-precipitate others, and a salt that helps at one concentration hurts at another, so selectivity is easily lost.
Verification¶
Does it exist? Confirmed. This work's DOI resolves to a registered record, which fixes its identity. That is all it fixes.
Does it back the claim? Not recorded. The single citation of this work carries no recorded support check.
Support is checked per citation rather than per work — the same source can be cited soundly in one article and wrongly in another. Per-citation recording began recently, so a citation with no recorded check is a gap in the record rather than evidence it went unchecked.
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Registry ID ref:bc74cb6a3a9e · see in the full table