Topographic reorganization of somatosensory cortical areas 3b and 1 in adult monkeys following restricted deafferentation¶
Merzenich, M. M., Kaas, J. H., Wall, J., Nelson, R. J., Sur, M., & Felleman, D. (1983). Topographic reorganization of somatosensory cortical areas 3b and 1 in adult monkeys following restricted deafferentation. Neuroscience.
Cited by¶
1 citation across 1 artifact.
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Domain-specific¶
- Somatotopy
- The map is established developmentally through molecular axon-guidance mechanisms and activity-dependent competition between afferent fibres, and it is plastic across the lifespan: amputation of a digit leads within weeks to expansion of neighbouring digit representations into the vacated cortical territory; intensive instrumental practice expands the representation of the practicing fingers relative to others; in chronic pain, the cortical representation of the affected body region can show systematic distortion
This sourceMerzenich and colleagues' deafferentation experiment, in which neighbouring skin-field representations expand to completely occupy vacated cortex in areas 3b and 1 of adult monkeys with topography preserved; the lesion is median nerve section rather than digit amputation, the time course is two to nine months, and the practice and chronic-pain clauses are not from this paper.
Supported in partVerified against the source
- The map is established developmentally through molecular axon-guidance mechanisms and activity-dependent competition between afferent fibres, and it is plastic across the lifespan: amputation of a digit leads within weeks to expansion of neighbouring digit representations into the vacated cortical territory; intensive instrumental practice expands the representation of the practicing fingers relative to others; in chronic pain, the cortical representation of the affected body region can show systematic distortion
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