International Union of Pharmacology Committee on Receptor Nomenclature and Drug Classification. XXXVIII. Update on Terms and Symbols in Quantitative Pharmacology.

Neubig, R. R., Spedding, M., Kenakin, T., & Christopoulos, A. (2003). International Union of Pharmacology Committee on Receptor Nomenclature and Drug Classification. XXXVIII. Update on Terms and Symbols in Quantitative Pharmacology. Pharmacological Reviews, 55(4), 597-606.

Type

Journal article

Intellectual base

Primary research

Year

2003

Volume

55

Issue

4

Pages

597-606

DOI

10.1124/pr.55.4.4

DOI registrant

Elsevier

Link

https://doi.org/10.1124/pr.55.4.4

Cited from

pharmacology_toxicology

Cited by

1 citation across 1 artifact.

Each citation links to the sentence it supports in the citing article.

Primes

• Antagonist
  • The formalism shows the structure quantitatively: a competitive antagonist shifts the agonist dose-response curve rightward in parallel without lowering the maximum, because raising agonist concentration can outcompete the blocker for the slot — the diagnostic signature of occupancy rather than destruction.

    This sourceDefines competitive (surmountable) antagonism — a parallel rightward shift of the agonist dose-response curve without depression of the maximum — versus insurmountable antagonism.

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