Chemical Stability of Pharmaceuticals¶
Connors, K. A., Amidon, & Stella, V. J. (1986). Chemical Stability of Pharmaceuticals: A Handbook for Pharmacists. Wiley.
Cited by¶
1 citation across 1 artifact.
Each citation links to the sentence it supports in the citing article.
Primes¶
- Temporal Decay and Degradation
- Pharmacology, biotechnology, and medicine: Drug potency decays in storage through chemical decomposition (affected by temperature, humidity, light), as Connors, Amidon, and Stella (1986) systematize in their canonical treatment of pharmaceutical chemical stability; vaccines degrade if not refrigerated; blood products have short shelf lives before degradation of viability; antibiotics become less efficacious if overused, as pathogenic resistance increases (a different kind of degradation—erosion of the drug's effectiveness); implanted medical devices (pacemakers, stents, prosthetics) degrade or fail due to material corrosion, mechanical wear, or fibrosis around implants.
This sourceCanonical pharmaceutical-stability reference: develops kinetic models, accelerated stability testing, and shelf-life prediction for drug substances and dosage forms.
- Pharmacology, biotechnology, and medicine: Drug potency decays in storage through chemical decomposition (affected by temperature, humidity, light), as Connors, Amidon, and Stella (1986) systematize in their canonical treatment of pharmaceutical chemical stability; vaccines degrade if not refrigerated; blood products have short shelf lives before degradation of viability; antibiotics become less efficacious if overused, as pathogenic resistance increases (a different kind of degradation—erosion of the drug's effectiveness); implanted medical devices (pacemakers, stents, prosthetics) degrade or fail due to material corrosion, mechanical wear, or fibrosis around implants.
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