ISIS-4: A randomised factorial trial assessing early oral captopril, oral mononitrate, and intravenous magnesium sulphate in 58 050 patients with suspected acute myocardial infarction¶
ISIS-4 Collaborative Group. (1995). ISIS-4: A randomised factorial trial assessing early oral captopril, oral mononitrate, and intravenous magnesium sulphate in 58 050 patients with suspected acute myocardial infarction. The Lancet, 6736(95).
Cited by¶
1 citation across 1 artifact.
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Domain-specific¶
- Funnel Plot Asymmetry
- Then the very large ISIS-4 trial (1995, ~58,000 patients) found no mortality benefit, landing near the null exactly where the missing small studies should have scattered.
This sourceReports the trial itself: 58,050 patients randomised in 1995, with intravenous magnesium sulphate showing no reduction in 5-week mortality (7.64% versus 7.24% control); the reading of that null as filling the funnel's empty quadrant is Egger et al.'s, not the trial's.
- Then the very large ISIS-4 trial (1995, ~58,000 patients) found no mortality benefit, landing near the null exactly where the missing small studies should have scattered.
Verification¶
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Registry ID ref:c031ef0a8c95 · see in the full table