ISIS-4: A randomised factorial trial assessing early oral captopril, oral mononitrate, and intravenous magnesium sulphate in 58 050 patients with suspected acute myocardial infarction

ISIS-4 Collaborative Group. (1995). ISIS-4: A randomised factorial trial assessing early oral captopril, oral mononitrate, and intravenous magnesium sulphate in 58 050 patients with suspected acute myocardial infarction. The Lancet.

Type

Journal article

Intellectual base

Primary research

Year

1995

ISSN

0140-6736

DOI

10.1016/s0140-6736(95)90865-x

DOI registrant

Elsevier

Link

https://doi.org/10.1016/s0140-6736(95)90865-x

Cited by

1 citation across 1 artifact.

Each citation links to the sentence it supports in the citing article.

Domain-specific

• Funnel Plot Asymmetry
  • Then the very large ISIS-4 trial (1995, ~58,000 patients) found no mortality benefit, landing near the null exactly where the missing small studies should have scattered.

    This sourceReports the trial itself: 58,050 patients randomised in 1995, with intravenous magnesium sulphate showing no reduction in 5-week mortality (7.64% versus 7.24% control); the reading of that null as filling the funnel's empty quadrant is Egger et al.'s, not the trial's.

    Supported in partVerified against the source

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Verification

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Registry ID ref:c031ef0a8c95 · see in the full table