Guidelines for Carcinogen Risk Assessment¶
U.S. Environmental Protection Agency. (2005). Guidelines for Carcinogen Risk Assessment.
Cited by¶
2 citations across 2 artifacts.
Each citation links to the sentence it supports in the citing article.
Primes¶
- Dose-Response Relationship
- Not equivalent to threshold: thresholds are a feature (or absence thereof) of the relationship; the relationship itself is the full functional mapping, a distinction the U.S. EPA's Guidelines for Carcinogen Risk Assessment (2005) makes operative when it instructs assessors to specify which dose-response model (linear no-threshold, threshold, nonlinear) is appropriate to a given mode of action.
This sourceRisk Assessment Forum, Washington, DC. Regulatory framework instructing assessors to specify which dose-response model (linear no-threshold, threshold, nonlinear) fits a given mode of action; supports D47-024 (threshold vs nonthreshold as a model choice, not an intrinsic property of the relationship).
- Not equivalent to threshold: thresholds are a feature (or absence thereof) of the relationship; the relationship itself is the full functional mapping, a distinction the U.S. EPA's Guidelines for Carcinogen Risk Assessment (2005) makes operative when it instructs assessors to specify which dose-response model (linear no-threshold, threshold, nonlinear) is appropriate to a given mode of action.
- Threshold
- Regulatory frameworks set the OEL as a daily threshold, but the mechanism driving actual harm is cumulative, a tension the U.S. EPA (2005) addresses head-on in its Carcinogen Risk Assessment Guidelines, which formalize the gap between single-exposure thresholds and cumulative-dose risk for long-latency carcinogens.
This sourceRisk Assessment Forum, Washington, DC. Regulatory framework for carcinogen risk assessment: formalizes the gap between single-exposure thresholds and cumulative-dose risk for long-latency carcinogens, including default low-dose linear extrapolation when threshold mechanisms cannot be established.
- Regulatory frameworks set the OEL as a daily threshold, but the mechanism driving actual harm is cumulative, a tension the U.S. EPA (2005) addresses head-on in its Carcinogen Risk Assessment Guidelines, which formalize the gap between single-exposure thresholds and cumulative-dose risk for long-latency carcinogens.
Verification¶
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Registry ID ref:c21c9c86dc41 · see in the full table