The population genetics of antibiotic resistance¶
MacLean, R. C., Hall, A. R., Perron, G. G., & Buckling, A. (2010). The population genetics of antibiotic resistance: integrating molecular mechanisms and treatment contexts. Nature Reviews Genetics, 11(6), 405-414.
Cited by¶
2 citations across 2 artifacts.
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Primes¶
- Natural Selection
- The selection pressure is the antibiotic itself: in its presence, susceptible cells die and resistant cells survive and reproduce, so the drug confers a stark differential reproductive success keyed to the variant's resistance.
This sourceDocuments how antibiotic exposure confers differential reproductive success on resistant variants, enriching their frequency in the bacterial population over generations.
- The selection pressure is the antibiotic itself: in its presence, susceptible cells die and resistant cells survive and reproduce, so the drug confers a stark differential reproductive success keyed to the variant's resistance.
- Vaccine Escape
- Sub-lethal or incomplete dosing creates a strong selection differential favoring resistant lineages, which come to dominate while the drug's intrinsic mechanism is unchanged — the coverage falls because the population moved, not because the drug eroded.
This sourceSub-lethal exposure selecting resistant lineages while the drug mechanism is unchanged.
- Sub-lethal or incomplete dosing creates a strong selection differential favoring resistant lineages, which come to dominate while the drug's intrinsic mechanism is unchanged — the coverage falls because the population moved, not because the drug eroded.
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