The population genetics of antibiotic resistance¶
MacLean, R. C., Hall, A. R., Perron, G. G., & Buckling, A. (2010). The population genetics of antibiotic resistance: integrating molecular mechanisms and treatment contexts. Nature Reviews Genetics, 11(6), 405-414.
Cited by¶
2 citations across 2 artifacts.
Each citation links to the sentence it supports in the citing article.
Primes¶
- Natural Selection
- The selection pressure is the antibiotic itself: in its presence, susceptible cells die and resistant cells survive and reproduce, so the drug confers a stark differential reproductive success keyed to the variant's resistance.
This sourceDocuments how antibiotic exposure confers differential reproductive success on resistant variants, enriching their frequency in the bacterial population over generations.
Supported in partVerified against the publisher's abstract
The review's abstract backs the selection half of the claim -- antibiotic dose strongly selects for resistant strains -- but states nothing about heritability or passage to daughter cells.
“the strength of selection for resistance increases with antibiotic dose. Most experiments select for resistance under antibiotic doses that prevent growth of wild-type strains, implying strong selection for resistance.”
- The selection pressure is the antibiotic itself: in its presence, susceptible cells die and resistant cells survive and reproduce, so the drug confers a stark differential reproductive success keyed to the variant's resistance.
- Vaccine Escape
- Sub-lethal or incomplete dosing creates a strong selection differential favoring resistant lineages, which come to dominate while the drug's intrinsic mechanism is unchanged — the coverage falls because the population moved, not because the drug eroded.
This sourceSub-lethal exposure selecting resistant lineages while the drug mechanism is unchanged.
Supported in partVerified against the publisher's abstract
Only this review's abstract was obtained; it frames resistance evolution as driven by drug dose and treatment ecology but never states that sub-lethal or incomplete dosing selects resistant lineages.
“This is because resistance evolution involves a complex interplay between the specific drug, bacterial genetics and both natural and treatment ecology.”
- Sub-lethal or incomplete dosing creates a strong selection differential favoring resistant lineages, which come to dominate while the drug's intrinsic mechanism is unchanged — the coverage falls because the population moved, not because the drug eroded.
Verification¶
Does it exist? Confirmed. This work's DOI resolves to a registered record, which fixes its identity. That is all it fixes.
Does it back the claim? Read against the text for 2 of 2 citations: 2 supported in part. Each verdict is shown under its citation below, with what in the work backs the sentence.
Support is checked per citation rather than per work — the same source can be cited soundly in one article and wrongly in another. Per-citation recording began recently, so a citation with no recorded check is a gap in the record rather than evidence it went unchecked.
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