Mechanism-Based Inhibition of Cytochrome P450 3A4 by Therapeutic Drugs¶
Zhou. (2005). Mechanism-Based Inhibition of Cytochrome P450 3A4 by Therapeutic Drugs.
Cited by¶
1 citation across 1 artifact.
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Domain-specific¶
- Enzyme Inhibition
- This last mode, exemplified by clarithromycin and erythromycin as time-dependent CYP3A4 inhibitors and by organophosphate pesticides as irreversible inhibitors of acetylcholinesterase, produces the most durable and clinically hazardous interactions.
This sourceReview listing clarithromycin and erythromycin among clinically important mechanism-based CYP3A4 inhibitors and reporting that mechanism-based CYP3A4 inhibition causes more frequent drug-drug interactions that can lead to fatal events, the inactivated enzyme needing replacement by new synthesis.
Supported in partVerified against the work's full text
“Compared with reversible inhibition of CYP3A4, mechanism-based inhibition of CYP3A4 more frequently cause pharmacokinetic-pharmacodynamic drug-drug interactions”
- This last mode, exemplified by clarithromycin and erythromycin as time-dependent CYP3A4 inhibitors and by organophosphate pesticides as irreversible inhibitors of acetylcholinesterase, produces the most durable and clinically hazardous interactions.
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