The efficiency of multi-target drugs¶
CSERMELY, P., AGOSTON, V., & PONGOR, S. (2005). The efficiency of multi-target drugs: the network approach might help drug design. Trends in Pharmacological Sciences, 26(4), 178-182.
Cited by¶
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Primes¶
- Inhibition
- From them follow inferences that port directly: a narrow inhibitor with side effects is often worse than a weaker, cleaner one, because specificity frequently matters more than potency; an irreversible block is a different instrument from a switchable one and carries different risk; and stacking several weak, specific inhibitors can outperform a single strong, non-specific one.
This sourceArgues that low-affinity, multi-target (partial) inhibition can perturb a network more efficiently than a single strong, non-specific block — the rationale that stacking weak specific inhibitors can outperform one strong non-specific one.
- From them follow inferences that port directly: a narrow inhibitor with side effects is often worse than a weaker, cleaner one, because specificity frequently matters more than potency; an irreversible block is a different instrument from a switchable one and carries different risk; and stacking several weak, specific inhibitors can outperform a single strong, non-specific one.
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Registry ID ref:c6b4e428e51a · see in the full table