Clinical pharmacokinetics and pharmacodynamics of warfarin

Holford, N. H. G. (1986). Clinical pharmacokinetics and pharmacodynamics of warfarin: Understanding the dose-effect relationship. 11(6), 483-504.

Type

Journal article

Intellectual base

Primary research

Year

1986

Volume

11

Issue

6

Pages

483-504

DOI registrant

Springer Nature

Link

https://doi.org/10.2165/00003088-198611060-00005matched

Cited from

pharmacology_toxicology

Cited by

1 citation across 1 artifact.

Each citation links to the sentence it supports in the citing article.

Primes

• Therapeutic Window
  • Warfarin's narrow therapeutic window in anticoagulation: Warfarin is a vitamin K antagonist with anticoagulant effect; its INR (international normalized ratio) target is typically 2.0–3.0 for most indications (e.g., atrial fibrillation, mechanical heart valve), with the underlying PK-PD model and inter-individual variability characterized by Holford (1986) in his classic Clinical Pharmacokinetics analysis of warfarin dosing.

    This sourceClassic PK-PD model of warfarin: derives the narrow INR window from anticoagulant dose-response, characterizes inter-individual variability, and grounds the operational requirement for INR monitoring.

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