Linkage Disequilibrium — Understanding the Evolutionary Past and Mapping the Medical Future.

Slatkin, M. (2008). Linkage Disequilibrium — Understanding the Evolutionary Past and Mapping the Medical Future. Nature Reviews Genetics, 9, 477-485.

Type

Journal article

Intellectual base

Primary research

Year

2008

Volume

9

Pages

477-485

DOI

10.1038/nrg2361

DOI registrant

Springer Nature

Link

https://doi.org/10.1038/nrg2361

Cited from

literature_literary_theory

Cited by

1 citation across 1 artifact.

Each citation links to the sentence it supports in the citing article.

Primes

• Metonymy
  • Cartography and genetics. A flagged landmark stands for the surrounding area; a postal code for a neighborhood; a genetic marker contiguous on the chromosome stands in for the linked gene in association studies — linkage is metonymy applied to inheritance.

    This sourceReviews linkage disequilibrium and tagging markers: a marker allele contiguous on the chromosome stands in for a linked (often unobserved) causal variant in association studies — metonymy applied to inheritance.

    Supported in partVerified against the work's full text

    Slatkin supports the genetics half: markers in strong LD with closely linked disease loci underpin association mapping; the metonymy framing and the cartography examples are not in the article.

    “Rare marker alleles in strong LD with a monogenic disease locus have to be closely linked to the causative locus.”

    Read by an automated reader; not a human review. How support was checked

Verification

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