Casarett and Doull's Toxicology¶
Klaassen, C. D. (2018). Casarett and Doull's Toxicology: The Basic Science of Poisons. McGraw-Hill.
Cited by¶
3 citations across 3 artifacts.
Each citation links to the sentence it supports in the citing article.
Primes¶
- Contact-Response Decomposition
- A coastal community's flood damage factors into how much surge reaches it and how badly each unit of surge damages it. Pharmacology and toxicology: harm = dose × responsiveness; the dose-response curve is the per-unit response term and bioavailability sits on the contact side.
This sourceStandard reference on the dose-response relationship, with the dose-response curve as the per-unit response term and bioavailability on the exposure side.
- A coastal community's flood damage factors into how much surge reaches it and how badly each unit of surge damages it. Pharmacology and toxicology: harm = dose × responsiveness; the dose-response curve is the per-unit response term and bioavailability sits on the contact side.
- Dose-Response Relationship
- The relationship is the quantitative bedrock of pharmacology, toxicology, radiation biology, ecotoxicology, and any field where input intensity and measurable effect are both specifiable, as Klaassen (2018) develops in the standard toxicology reference.
This sourceStandard toxicology reference; supports D47-018 (dose-response as the quantitative bedrock of toxicology, carcinogen assessment, and exposure-limit setting). NOTE: the pre-existing annotation about metallothionein/CYP450 tolerance vs population resistance is mis-pasted from the Tolerance prime and does not describe the D47-018 claim.
- The relationship is the quantitative bedrock of pharmacology, toxicology, radiation biology, ecotoxicology, and any field where input intensity and measurable effect are both specifiable, as Klaassen (2018) develops in the standard toxicology reference.
- Tolerance
- Not population-level resistance: Antimicrobial resistance, pesticide resistance in insects, or resistance to antiretroviral drugs in a viral population are genetically-mediated shifts in population response, driven by selection of resistant variants—a mechanism Klaassen (2018) explicitly distinguishes from individual-organism tolerance in Casarett and Doull's Toxicology.
This sourceStandard toxicology reference: distinguishes individual-organism physiological tolerance (within-lifetime adaptation through metallothionein induction, CYP450 upregulation, etc.) from population-level genetic resistance (selection of resistant variants) as mechanistically and temporally distinct phenomena.
- Not population-level resistance: Antimicrobial resistance, pesticide resistance in insects, or resistance to antiretroviral drugs in a viral population are genetically-mediated shifts in population response, driven by selection of resistant variants—a mechanism Klaassen (2018) explicitly distinguishes from individual-organism tolerance in Casarett and Doull's Toxicology.
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