Hemorrhage During Warfarin Therapy Associated With Cotrimoxazole and Other Urinary Tract Anti-infective Agents

Fischer. (2010). Hemorrhage During Warfarin Therapy Associated With Cotrimoxazole and Other Urinary Tract Anti-infective Agents. Archives of Internal Medicine.

Type

Journal article

Intellectual base

Primary research

Year

2010

DOI

10.1001/archinternmed.2010.37

Link

https://doi.org/10.1001/archinternmed.2010.37

Cited by

1 citation across 1 artifact.

Domain-specific

• Adverse Drug Event
  • A classic precipitating interaction: a patient stable on warfarin is prescribed co-trimoxazole (which contains sulfamethoxazole) for an infection; sulfamethoxazole inhibits the CYP2C9 enzyme that clears warfarin, warfarin levels rise, the INR climbs well above range, and a gastrointestinal or intracranial bleed follows — even though every prescription was written and taken correctly

Verification

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Registry ID ref:c9ce7fbbb5f2 · see in the full table