The TD50: a proposed general convention for the numerical description of the carcinogenic potency of chemicals in chronic-exposure animal experiments¶
Peto. (1984). The TD50: a proposed general convention for the numerical description of the carcinogenic potency of chemicals in chronic-exposure animal experiments: a proposed general convention for the numerical description of the carcinogenic potency of chemicals in chronic-exposure animal experiments. Environmental Health Perspectives.
Cited by¶
1 citation across 1 artifact.
Each citation links to the sentence it supports in the citing article.
Domain-specific¶
- Potency
- Clinical and receptor pharmacology — the home use: ED50 for therapeutic effect, comparative-potency rankings (morphine ~10× codeine), and receptor-binding affinity (Kd) as the mechanistic predictor of where the dose-response curve sits. In vitro and screening pharmacology — IC50 for inhibition and EC50 in functional assays, the same half-maximal construct used to rank compounds in drug discovery before whole-organism testing. Toxicology and risk assessment — LD50 for lethality, threshold doses, and potency ranking of carcinogens (the carcinogenic-potency database's dose-per-tumour scalar)
This sourceDefinition of the TD50 convention - the chronic daily dose rate that would halve the actuarially adjusted percentage of tumour-free animals - as the standard measure of carcinogenic potency.
Supported in partVerified against the work's full text
“in this paper we recommend that the TD50 (tumorigenic dose rate 50) be used”
- Clinical and receptor pharmacology — the home use: ED50 for therapeutic effect, comparative-potency rankings (morphine ~10× codeine), and receptor-binding affinity (Kd) as the mechanistic predictor of where the dose-response curve sits. In vitro and screening pharmacology — IC50 for inhibition and EC50 in functional assays, the same half-maximal construct used to rank compounds in drug discovery before whole-organism testing. Toxicology and risk assessment — LD50 for lethality, threshold doses, and potency ranking of carcinogens (the carcinogenic-potency database's dose-per-tumour scalar)
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Registry ID ref:cc081e490e42 · see in the full table