Evolution at Two Levels¶
Carroll, S. B. (2005). Evolution at Two Levels: On Genes and Form. PLoS Biology, 3(7).
Cited by¶
1 citation across 1 artifact.
Each citation links to the sentence it supports in the citing article.
Primes¶
- Open-Closed Principle
- In genetics and gene regulation, deeply conserved core protein domains are paired with variable regulatory regions, and evolution proceeds largely by tinkering with regulation while leaving the core machinery untouched.
This sourceArgues evolution proceeds largely by changes to cis-regulatory regions while conserved coding sequences (the catalytic core) remain untouched.
Supported in partVerified against the work's full text
Carroll argues anatomical evolution runs primarily through cis-regulatory 'tinkering' while conserved protein coding sequences stay constrained, but he limits this to anatomy and documents coding change.
“Thus, while the coding sequences of the structural and regulatory proteins are constrained by pleiotropy, modular cis -regulatory regions enable a great diversity of patterns to arise from alterations in regulatory circuits”
- In genetics and gene regulation, deeply conserved core protein domains are paired with variable regulatory regions, and evolution proceeds largely by tinkering with regulation while leaving the core machinery untouched.
Verification¶
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