Hypoxia-Inducible Factors in Physiology and Medicine¶
Semenza. (2012). Hypoxia-Inducible Factors in Physiology and Medicine. Cell.
Cited by¶
1 citation across 1 artifact.
Each citation links to the sentence it supports in the citing article.
Domain-specific¶
- Hypoxia
- In parallel, prolyl hydroxylase enzymes that normally tag HIF-1α for proteasomal degradation become inactive when oxygen is scarce; HIF-1α stabilises, dimerises with HIF-1β, and transactivates a battery of target genes that coordinate the adaptive response: erythropoietin (EPO) stimulates erythropoiesis to increase oxygen-carrying capacity; vascular endothelial growth factor (VEGF) promotes angiogenesis; glycolytic enzymes are upregulated; carbonic anhydrase IX buffers the lactate-driven acidosis.
This sourceA review presenting the hypoxia-inducible factors as transcriptional activators that act as master regulators of oxygen homeostasis in metazoans.
Supported in partVerified against a saved copy of the source
“The hypoxia-inducible factors (HIFs) are transcriptional activators that function as master regulators of oxygen homeostasis in all metazoan species.”
- In parallel, prolyl hydroxylase enzymes that normally tag HIF-1α for proteasomal degradation become inactive when oxygen is scarce; HIF-1α stabilises, dimerises with HIF-1β, and transactivates a battery of target genes that coordinate the adaptive response: erythropoietin (EPO) stimulates erythropoiesis to increase oxygen-carrying capacity; vascular endothelial growth factor (VEGF) promotes angiogenesis; glycolytic enzymes are upregulated; carbonic anhydrase IX buffers the lactate-driven acidosis.
Verification¶
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Registry ID ref:d029ebbe35fb · see in the full table