Validating therapeutic targets through human genetics

Plenge, S., & Altshuler. (2013). Validating therapeutic targets through human genetics.

Type

Unclassified

Intellectual base

Unclassified

Year

2013

DOI

10.1038/nrd4051

DOI registrant

Springer Nature

Link

https://doi.org/10.1038/nrd4051

Cited by

1 citation across 1 artifact.

Each citation links to the sentence it supports in the citing article.

Domain-specific

• Instrumental variable
  • This logic anticipated and supported the development of PCSK9-inhibitor drugs

    This sourceReview arguing that human-genetic evidence validates drug targets, with PCSK9 loss-of-function genetics as the precedent for inhibitor drugs that mimic the mutations.

    SupportedVerified against the source

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