Buprenorphine¶
Lutfy, & Cowan. (2004). Buprenorphine: A Unique Drug with Complex Pharmacology. Current Neuropharmacology.
Cited by¶
1 citation across 1 artifact.
Each citation links to the sentence it supports in the citing article.
Domain-specific¶
- Efficacy
- Buprenorphine can be more potent (lower EC₅₀) yet less efficacious
This sourceLutfy and Cowan's review of buprenorphine's mixed agonist-antagonist pharmacology, which attributes its ceiling effect to partial agonism at the mu receptor.
Supported in partVerified against the publisher's abstract
“Partial agonism at the mu opioid receptor and, in some cases, antagonism at the kappa or delta opioid receptor have been considered as possible underlying mechanisms for the ceiling effect and bell-shaped dose-response curve of buprenorphine.”
- Buprenorphine can be more potent (lower EC₅₀) yet less efficacious
Verification¶
Does it exist? Not checked yet. This work's DOI is recorded above but has not been resolved against an external catalogue, so nothing here confirms the work exists.
Does it back the claim? Read against the text for 1 of 1 citation: 1 supported in part. Each verdict is shown under its citation below, with what in the work backs the sentence.
Support is checked per citation rather than per work — the same source can be cited soundly in one article and wrongly in another. Per-citation recording began recently, so a citation with no recorded check is a gap in the record rather than evidence it went unchecked.
See how references were verified.
Registry ID ref:d1df3ab7973e · see in the full table