Watch Out, No Brakes! Impaired Inhibition Results in Hyperexcitable Networks.¶
Stafstrom, C. E. (2015). Watch Out, No Brakes! Impaired Inhibition Results in Hyperexcitable Networks. Epilepsy Currents, 15(6), 342-343.
Cited by¶
1 citation across 1 artifact.
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Primes¶
- Feedforward Inhibition
- The mis-calibration failure mode is biologically real: too strong an interneuron over-suppresses (a silent dead cell), too weak permits runaway excitation (the hyperexcitability seen when feedforward inhibition is impaired in epilepsy).
This sourceCommentary on an SCN1A model showing interneuron hypoexcitability (loss of inhibitory braking) producing network hyperexcitability and seizures — impaired feedforward/feedback inhibition manifesting as runaway excitation.
- The mis-calibration failure mode is biologically real: too strong an interneuron over-suppresses (a silent dead cell), too weak permits runaway excitation (the hyperexcitability seen when feedforward inhibition is impaired in epilepsy).
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Registry ID ref:d2b4b1ea1089 · see in the full table