Watch Out, No Brakes! Impaired Inhibition Results in Hyperexcitable Networks.¶
Stafstrom, C. E. (2015). Watch Out, No Brakes! Impaired Inhibition Results in Hyperexcitable Networks. Epilepsy Currents, 15(6), 342-343.
Cited by¶
1 citation across 1 artifact.
Each citation links to the sentence it supports in the citing article.
Primes¶
- Feedforward Inhibition
- The mis-calibration failure mode is biologically real: too strong an interneuron over-suppresses (a silent dead cell), too weak permits runaway excitation (the hyperexcitability seen when feedforward inhibition is impaired in epilepsy).
This sourceCommentary on an SCN1A model showing interneuron hypoexcitability (loss of inhibitory braking) producing network hyperexcitability and seizures — impaired feedforward/feedback inhibition manifesting as runaway excitation.
- The mis-calibration failure mode is biologically real: too strong an interneuron over-suppresses (a silent dead cell), too weak permits runaway excitation (the hyperexcitability seen when feedforward inhibition is impaired in epilepsy).
Verification¶
Does it exist? Not checked yet. This entry carries no identifier to resolve. It was extracted from the citation as written in the article, normalized, and deduplicated against the rest of the registry.
Does it back the claim? Not recorded. The single citation of this work carries no recorded support check.
Support is checked per citation rather than per work — the same source can be cited soundly in one article and wrongly in another. Per-citation recording began recently, so a citation with no recorded check is a gap in the record rather than evidence it went unchecked.
See how references were verified.
Registry ID ref:d2b4b1ea1089 · see in the full table