The Mathematical Approach to Physiological Problems¶
Riggs, D. S. (1963). The Mathematical Approach to Physiological Problems: A Critical Primer.
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Primes¶
- PK/PD Modeling (Pharmacokinetics / Pharmacodynamics)
- The cross-domain template — decomposing a stimulus-response system into a kinetic stage and an effect stage and reasoning compositionally — generalizes the abstract approach Riggs (1963) develops in his mathematical treatment of physiological problems.
This sourceWilliams & Wilkins. Establishes the abstract template of decomposing biological input-output systems into kinetic compartments and effect stages; the cross-domain reasoning move that licenses PK/PD analogies in non-pharmacological systems.
- The cross-domain template — decomposing a stimulus-response system into a kinetic stage and an effect stage and reasoning compositionally — generalizes the abstract approach Riggs (1963) develops in his mathematical treatment of physiological problems.
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