Mechanism-Based Enzyme Inactivators¶
Silverman, R. B. (1995). Mechanism-Based Enzyme Inactivators. Methods in Enzymology.
Cited by¶
1 citation across 1 artifact.
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Mechanisms¶
- Active-Site Inhibitor
- A mechanism-based (suicide) inhibitor is turned by the enzyme into a reactive species — occupancy without inertness, which can produce the very reactivity the design meant to prevent, or irreversible off-target damage.
This sourceDefines a mechanism-based enzyme inactivator as a compound transformed by the target enzyme’s catalytic machinery into an inhibitory species.
- A mechanism-based (suicide) inhibitor is turned by the enzyme into a reactive species — occupancy without inertness, which can produce the very reactivity the design meant to prevent, or irreversible off-target damage.
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