Prodrugs¶
Rautio, J., Kumpulainen, H., Heimbach, T., Oliyai, R., Oh, D., Järvinen, T., & Savolainen, J. (2008). Prodrugs: Design and Clinical Applications. Nature Reviews Drug Discovery, 7(3), 255-270.
Cited by¶
1 citation across 1 artifact.
Each citation links to the sentence it supports in the citing article.
Primes¶
- Bycatch
- The fisheries intervention catalogue — refine the selector, change the capture phase, enable release of non-targets — maps onto receptor-specificity engineering, prodrug design that activates selectively in target tissue, and antidote co-administration in pharmacology.
This sourceReviews prodrug strategies that activate selectively in target tissue to improve specificity and reduce off-target effects.
Supported in partVerified against the publisher's abstract
The abstract backs prodrugs as an established in-vivo drug-release strategy, but not target-tissue-selective activation or the other two pharmacological mappings.
“Prodrugs are bioreversible derivatives of drug molecules that undergo an enzymatic and/or chemical transformation in vivo to release the active parent drug, which can then exert the desired pharmacological effect.”
- The fisheries intervention catalogue — refine the selector, change the capture phase, enable release of non-targets — maps onto receptor-specificity engineering, prodrug design that activates selectively in target tissue, and antidote co-administration in pharmacology.
Verification¶
Does it exist? Confirmed. This work's DOI resolves to a registered record, which fixes its identity. That is all it fixes.
Does it back the claim? Read against the text for 1 of 1 citation: 1 supported in part. Each verdict is shown under its citation below, with what in the work backs the sentence.
Support is checked per citation rather than per work — the same source can be cited soundly in one article and wrongly in another. Per-citation recording began recently, so a citation with no recorded check is a gap in the record rather than evidence it went unchecked.
See how references were verified.
Registry ID ref:d884f2b524b4 · see in the full table