Ecological Theory Suggests That Antimicrobial Cycling Will Not Reduce Antimicrobial Resistance in Hospitals.¶
Bergstrom, C. T., Lo, M., & Lipsitch, M. (2004). Ecological Theory Suggests That Antimicrobial Cycling Will Not Reduce Antimicrobial Resistance in Hospitals. Proceedings of the National Academy of Sciences, 101(36), 13285-13290.
Cited by¶
2 citations across 2 artifacts.
Each citation links to the sentence it supports in the citing article.
Primes¶
- Mixed Strategy
- In antibiotic stewardship rotating antibiotics across patients or wards prevents pathogens from converging on a single resistance profile.
This sourceModeling of antibiotic rotation/mixing across patients to prevent pathogen convergence on a single resistance profile.
- In antibiotic stewardship rotating antibiotics across patients or wards prevents pathogens from converging on a single resistance profile.
- Vaccine Escape
- Rotation — cycling the barrier so the selection pressure is not durable enough to fix a single escape variant (antibiotic cycling, key rotation, rule churn).
This sourceAntibiotic cycling/rotation as a strategy to deny selection pressure durability, and its limits.
Supported in partVerified against the publisher's abstract
The abstract frames antimicrobial cycling as a leading candidate strategy for slowing resistance but concludes it is unlikely to work, so it qualifies rather than confirms the rotation strategy.
“We find that cycling is unlikely to reduce either the evolution or the spread of antibiotic resistance. Alternative drug-use strategies such as mixing, in which each treated patient receives one of several drug classes used simultaneously in the hospital, are predicted to be more effective.”
- Rotation — cycling the barrier so the selection pressure is not durable enough to fix a single escape variant (antibiotic cycling, key rotation, rule churn).
Verification¶
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