Clinical Pharmacokinetics of Ethanol¶
Holford, N. H. G. (1987). Clinical Pharmacokinetics of Ethanol. Clinical Pharmacokinetics, 13(5), 273-292.
Cited by¶
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Primes¶
- Clearance Rate
- Ethanol exposes the contrasting zero-order regime: the clearing enzyme (alcohol dehydrogenase) saturates at modest concentrations, so clearance is capped at a fixed maximum rate and any intake above that cap accumulates with no finite steady state — which is exactly why "modest" extra drinks produce disproportionately high and sustained blood-alcohol levels.
This sourceDocuments zero-order (capacity-limited) ethanol elimination via saturated alcohol dehydrogenase, so intake above the cap accumulates with no finite steady state.
- Ethanol exposes the contrasting zero-order regime: the clearing enzyme (alcohol dehydrogenase) saturates at modest concentrations, so clearance is capped at a fixed maximum rate and any intake above that cap accumulates with no finite steady state — which is exactly why "modest" extra drinks produce disproportionately high and sustained blood-alcohol levels.
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