Defining hormesis¶
Calabrese, E. J., & Baldwin, L. A. (2002). Defining hormesis. Human & Experimental Toxicology, 21(2), 91-97.
Cited by¶
2 citations across 2 artifacts.
Each citation links to the sentence it supports in the citing article.
Primes¶
- Stressor Induced Adaptation
- The same shape is named hormesis in toxicology and progressive overload in exercise physiology, and across all three the structural logic is identical: a sub-injurious dose of stress provokes an adaptive response that overshoots the original baseline, leaving the system stronger than before it was perturbed.
This sourceDocuments the biphasic (inverted-U) dose-response as a generalizable adaptive shape across pharmacology, toxicology, and cell biology, supplying the single three-regime curve (sub-threshold, strengthening band, damage) shared by desirable difficulties, hormesis, and progressive overload.
- The same shape is named hormesis in toxicology and progressive overload in exercise physiology, and across all three the structural logic is identical: a sub-injurious dose of stress provokes an adaptive response that overshoots the original baseline, leaving the system stronger than before it was perturbed.
Mechanisms¶
- Response-Curve Calibration
- Its strength is replacing assumed resonance with a measured one: by baselining and varying a single knob it produces an actual dose-response (or timing-response) curve, catching non-monotonic shapes — thresholds, plateaus, and the falling edge where more input reduces response, as in hormesis.
This sourceDefines hormesis as a non-monotonic dose–response in which low and high doses produce effects in opposite directions.
- Its strength is replacing assumed resonance with a measured one: by baselining and varying a single knob it produces an actual dose-response (or timing-response) curve, catching non-monotonic shapes — thresholds, plateaus, and the falling edge where more input reduces response, as in hormesis.
Verification¶
Does it exist? Not checked yet. This entry carries no identifier to resolve. It was extracted from the citation as written in the article, normalized, and deduplicated against the rest of the registry.
Does it back the claim? Not recorded. Neither this nor any other of the 2 citations of this work carries a recorded support check.
Support is checked per citation rather than per work — the same source can be cited soundly in one article and wrongly in another. Per-citation recording began recently, so a citation with no recorded check is a gap in the record rather than evidence it went unchecked.
See how references were verified.
Registry ID ref:dadcbe0f5049 · see in the full table