The molecular hallmarks of epigenetic control¶
Allis, C. D., & Jenuwein, T. (2016). The molecular hallmarks of epigenetic control. Nature Reviews Genetics, 17(8), 487-500.
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Primes¶
- Immutability
- Biology (non-obvious): The genomic record in a differentiated somatic cell is largely treated as read-only; regulatory machinery modifies which genes are expressed rather than rewriting the stored sequence, so the original instructions are preserved even as cell behavior changes dramatically across the body and across a lifetime.
This sourceCanonical review of epigenetic regulation: the stored genomic sequence in differentiated cells is largely preserved unchanged while DNA methylation, histone modifications, and noncoding RNAs modulate which genes are expressed, altering cell behavior without rewriting the underlying record.
- Biology (non-obvious): The genomic record in a differentiated somatic cell is largely treated as read-only; regulatory machinery modifies which genes are expressed rather than rewriting the stored sequence, so the original instructions are preserved even as cell behavior changes dramatically across the body and across a lifetime.
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