The Norton-Simon hypothesis revisited¶
Norton, L. (1988). The Norton-Simon hypothesis revisited. Cancer Treatment Reports, 70(1), 163-169.
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Primes¶
- Therapeutic Window
- The chemotherapy literature illustrates this most starkly: Norton (1988), in articulating the Norton-Simon hypothesis, shows that tumor-shrinkage endpoints and long-term cure endpoints can imply opposite optimal dose schedules, even when each endpoint individually defines a clean window.
This sourceFoundational chemotherapy-scheduling argument: shows that single-endpoint optimization (tumor shrinkage at a fixed time) and multi-endpoint optimization (long-term cure across heterogeneous tumor populations) can imply different dose-intensity schedules, formalizing the multi-endpoint reduction failure mode.
- The chemotherapy literature illustrates this most starkly: Norton (1988), in articulating the Norton-Simon hypothesis, shows that tumor-shrinkage endpoints and long-term cure endpoints can imply opposite optimal dose schedules, even when each endpoint individually defines a clean window.
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